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Cat No. | Product Name | Synonyms | Targets |
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T3420 | CA-074 methyl ester | Cathepsin B Inhibitor IV,CA-074Me | Cysteine Protease |
CA-074 methyl ester (Cathepsin B Inhibitor IV) is a specific inhibitor of Cathepsin B with neuroprotective, anti-cancer, and anti-inflammatory effects. | |||
TQ0116 | LY 3000328 | Cathepsin S inhibitor | Cysteine Protease |
LY 3000328 (Cathepsin S inhibitor) is a potent, highly selective Cathepsin S (Cat S) inhibitor (IC50s: 7.7 and 1.67 nM for hCat S and mCat S). | |||
T60812 | Cathepsin X-IN-1 | Cysteine Protease | |
Cathepsin X-IN-1 (compound 25) reduces the migration of PC-3 cell with low cytotoxic that is a potent inhibitor of Cathepsin X (IC 50 = 7.13 μM) [1]. | |||
T12051 | MIV-247 | Cysteine Protease | |
MIV-247 is a selective and potent inhibitor of cathepsin S (Kis 2.1, 4.2, and 7.5 nM for human, mouse, and wild monkey cathepsin S, respectively), which attenuates mechanical anomalies in preclinical models of neuropathi... | |||
T13288 | VBY-825 | Cysteine Protease | |
VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V. | |||
T37504L | Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base) | Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base) | |
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E but not for B, H, or L. Cathepsin D and E FRET Substrate acetate can be used in mechanistic studies on cathepsins D and E studies... | |||
T21616 | L-006235 | L 006235 | Cysteine Protease |
L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM. | |||
T19347 | H-Arg-4MβNA | H-Arg-4MbNA | Others |
H-Arg-4MβNA (H-Arg-4MbNA) is a peptide that serves as a substrate for cathepsin H. The enzyme activity is often detected in gel electrophoresis. | |||
T8677 | 3,4 Dichloroisocoumarin | Others , Serine Protease , Cysteine Protease | |
3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor | |||
T12909 | SID 26681509 | Cysteine Protease , Parasite | |
SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM). | |||
T12188 | NB-360 | BACE | |
NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cat... | |||
T5149 | MC-Val-Cit-PAB | Others , AChR | |
MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker. | |||
T1850 | Balicatib | AAE581 | Cysteine Protease |
Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis. | |||
TP2056L | Acetyl-Calpastatin (184-210)(human) acetate | Acetyl-Calpastatin (184-210) (human) acetate(123714-50-1 Free base ) | Cysteine Protease |
Acetyl-Calpastatin (184-210)(human) acetate is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively. | |||
T3695 | Pepstatin | Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C | Amino Acids and Derivatives , Proteasome , HIV Protease , Autophagy |
Pepstatin (Pepsin Inhibitor S 735A) is a specific aspartic proteases inhibitor produced by actinomycetes, and inhibits the aspartic proteases cathepsin D, pepsin and renin. | |||
T18540 | Phe-Lys(Trt)-PAB | Others | |
Phe-Lys(Trt)-PAB is a cathepsin-cleavable linker utilized in the development of antibody-drug conjugates (ADCs)[1], serving as a crucial component for facilitating the release of therapeutic agents within targeted cells. | |||
T21509 | CA 074 | Cysteine Protease | |
CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates retinopathy and optic neuritis in experimental autoimmune encephalom... | |||
T6432 | Calpeptin | Apoptosis , Cysteine Protease , Proteasome | |
Calpeptin is a potent, cell-permeable calpain inhibitor. | |||
T3503 | MC-Val-Cit-PABC-PNP | Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate | Others , AChR |
MC-Val-Cit-PABC-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker. Protein- and peptide-drug conjugates hold a pr... | |||
T15641 | K777 | APC-3316 | P450 , Cysteine Protease , CCR |
K777 is a potent, orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 ... | |||
T27730 | KGP94 | KGP-94,KGP 94 | Cysteine Protease |
KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL). | |||
T26218 | SQ 32602 | SQ-32,602,SQ-32602,SQ32602,SQ 32,602,SQ32,602 | |
SQ 32602 is a cathepsin E inhibitor. | |||
T27989 | MDK0734 | Cathepsin B Inhinitor-42 | |
MDK0734 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities. | |||
T71603 | MV061194 | ||
MV061194 is a potent and selective cathepsin K (Cat K) inhibitor. | |||
T26217 | SQ 32056 | SQ32056,SQ 32,056,SQ32,056,SQ-32056,SQ-32,056 | |
SQ 32056 is a cathepsin E inhibitor. | |||
T35932 | Gly-Arg-AMC (hydrochloride) | ||
Gly-Arg-AMC is a fluorogenic substrate for cathepsin C.1 Upon enzymatic cleavage by cathepsin C, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify cathepsin C activity. AMC displays ... | |||
T37053 | Z-(L-Arg)-AMC (hydrochloride) | ||
Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H.1,2Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can b... | |||
T11554 | Cathepsin Inhibitor 2 | Cysteine Protease | |
Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM). | |||
T64159 | Cathepsin K inhibitor 2 | ||
Cathepsin K inhibitor 2 is a potent inhibitor of cathepsin K. Cathepsin K (Cat K) is a cysteine protease expressed under the control of the CTSK gene, which is closely related to osteoporosis and hydrolyses collagen. cat... | |||
T62659 | Cathepsin C-IN-4 | ||
Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM). | |||
T27661 | JNJ-10329670 | ||
JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity. | |||
T27660 | JNJ-10311795 | ||
JNJ-10311795, a dual inhibitor of the leukocyte Proteases Cathepsin G and Chymase, has therapeutic efficacy in animals models of inflammation. | |||
T71618 | Oxocarbazate | ||
Oxocarbazate, also known as CID23631927, is an inhibitor of human cathepsin L. In the cathepsin L inhibition assay, The oxocarbazate caused a time-dependent 17-fold drop in IC50 from 6.9 nM (no preincubation) to 0.4 nM ... | |||
T80105 | Z-Phe-Phe-Diazomethylketone | ||
Z-Phe-Phe-Diazomethylketone is a selective inhibitor of cathepsin L [1]. | |||
T72569 | Cathepsin L/S-IN-1 | ||
Cathepsin L/S-IN-1, a dual inhibitor targeting Cathepsin L and Cathepsin S, exhibits potent and selective inhibition with IC50 values of 4.10 μM and 1.79 μM, respectively. Demonstrating significant antimetastatic and inv... | |||
T15626 | JPM-OEt | Others | |
JPM-OEt is a broad spectrum cysteine cathepsin inhibitor with antitumor activity. JPM-OEt binds covalently in the active site and irreversibly inhibits the cysteine cathepsin family. | |||
T28003 | MDK7677 | Cathepsin B Inhinitor-17,MDK 7677 | |
MDK7677 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities. | |||
T26938 | CAA0225 | CAA 0225,CAA-0225 | |
CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis. | |||
T77826 | MC-Val-Cit-PAB-NH-C2-NH-Boc | ||
MC-Val-Cit-PAB-NH-C2-NH-Boc is a cathepsin-cleavable ADC linker utilized in constructing antibody-drug conjugates (ADCs) [1]. | |||
T72296 | Cathepsin K inhibitor 3 | ||
Cathepsin K Inhibitor 3, exhibiting an IC50 value of 0.5 nM, is a highly selective inhibitor of cathepsin K, featuring a favorable pharmacokinetic profile. It holds potential for use in studies of osteoarthritis (OA). | |||
T80739 | Z-FG-NHO-BzOME | ||
Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S, and papain [1]. | |||
T38469 | (Rac)-Z-Phe-Phe-FMK | Cathepsin L-IN-2 | Beta Amyloid , Cysteine Protease |
(Rac)-Z-Phe-Phe-FMK (Cathepsin L-IN-2) is a cathepsin L inhibitor that inhibits the tendency of β-amyloid to induce apoptotic changes . | |||
T18539 | Phe-Lys(Fmoc)-PAB | Others | |
Phe-Lys(Fmoc)-PAB is a cathepsin cleavable ADC linker employed in the conjugation of antibody-drug conjugates (ADCs)[1]. | |||
T80740 | Z-FG-NHO-Bz | ||
Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1]. | |||
T37504 | Cathepsin D and E FRET Substrate | ||
Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A. | |||
T70381 | GSK2793660 free base | ||
GSK-2793660 is a cathepsin C inhibitor that may be useful in the treatment of cystic fibrosis, noncystic fibrosis bronchiectasis, ANCA-associated vasculitis and bronchiectasis. | |||
T73220 | RO5461111 | ||
RO5461111, a highly specific and orally active Cathepsin S antagonist, exhibits potent inhibitory effects with IC50 values of 0.4 nM (human Cathepsin S) and 0.5 nM (murine Cathepsin S), respectively. It effectively suppr... | |||
T76010 | N-CBZ-Phe-Arg-AMC TFA | ||
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) TFA serves as a substrate for cathepsin, facilitating the evaluation of lysosomal cathepsin enzyme activity [1] [2]. | |||
T71198 | Eglin c (60-63) | ||
Eglin c (60-63) is a sequence of a peptide that has been studied for its inhibitory activity towards human leukocyte elastase, cathepsin G, porcine pancreatic elastase and alpha-chymotrypsin. | |||
T41236 | Z-FY-CHO | ||
Z-FY-CHO (Z-Phe-Tyr-CHO) is a specific and potent cathepsin L (CTSL) inhibitor [1] [2]. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6564 | Leupeptin Hemisulfate | Serine Protease , Cysteine Protease | |
Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and bloc... | |||
TJS2216 | Aurantiamide acetate | Asperglaucide | Cysteine Protease |
Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide aceta... | |||
T3417 | Amentoflavone | Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin | Apoptosis , P450 , Phospholipase , Reactive Oxygen Species , Opioid Receptor , COX , Antibacterial , RSV , Antifungal |
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib... | |||
T15702 | Lactacystin | Proteasome | |
Lactacystin is an antibiotic Streptomyces spp. the metabolite and is an effective and selective proteasome inhibitor (IC50: 4.8 μM for 20S proteasome). Lactacystin inhibits cell growth and induces neurite outgrowth and a... | |||
T72898 | Gallinamide A | ||
Gallinamide A is a potent inhibitor of cathepsin L with an IC 50 value of 17.6 pM. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01450 | Cathepsin A Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Cathepsin A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.8 kDa and the accession number is P16675-1. | |||
TMPY-00730 | Cathepsin A Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cathepsin A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53 kDa and the accession number is P10619-1. | |||
TMPY-00672 | Azurocidin/CAP37 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil... | |||
TMPJ-01204 | TPSAB1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(T... | |||
TMPY-01249 | Cathepsin V Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and t... | |||
TMPJ-00508 | CTSL Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cathepsin L is an enzyme. Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteinases. Cathepsin L plays a major role in antigen processing, tu... | |||
TMPY-00732 | Cathepsin C Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption. The lysosomal cysteine protease Cathepsin C (CTSC), also kno... | |||
TMPH-00437 | Cathepsin D Protein, Cricetulus griseus, Recombinant (His & SUMO) | Chinese hamster | E. coli |
N/A. Cathepsin D Protein, Cricetulus griseus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 53.3 kDa and the accession number is G3I4W7. | |||
TMPH-02566 | Cathepsin W Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
May have a specific function in the mechanism or regulation of T-cell cytolytic activity. Cathepsin W Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The pre... | |||
TMPH-03261 | Cathepsin D Protein, Rat, Recombinant (His & Myc) | Rat | E. coli |
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Cathepsin D Protein, Rat, Recombinant (His & Myc) is exp... | |||
TMPJ-00845 | CTSE Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cathepsin E (CTSE) is a gastric aspartyl protease that functions as a disulfide-linked homodimer. It is a member of the Peptidase C1 family, and has a specificity similar to that of Pepsin A and Cathepsin D. CTSE is loca... | |||
TMPJ-00708 | CST7 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Mouse Cystatin F belongs to cystatin superfamily, which encompasses proteins that contain multiple cystatin-like sequences. It has been shown that Cystatin F is selectively expressed by hematopoietic cells and may be a b... | |||
TMPY-01644 | Cystatin S Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cystatin-S, also known as Cystatin-4, Salivary acidic protein 1, Cystatin-SA-III and CST4, is a secreted protein which belongs to thecystatin family. Cystatin-4 / CST4 is expressed in submandibular and sublingual sali... | |||
TMPJ-01287 | Sialidase-1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues; it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cl... | |||
TMPJ-00869 | GLB1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
β Galactosidase is a lysosomal β Galactosidase that hydrolyzes the terminal β Galactose from Ganglioside and Keratan sulfate. In lysosome, the mature β Galactosidase protein associates with Cathepsin A and Neuraminidase ... | |||
TMPJ-00497 | CTSB Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, bot... | |||
TMPY-00729 | Cystatin D Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cystatins are natural inhibitors of papain-like (family C1) and legumain-related (family C13) cysteine peptidases. The mammalian cystatin superfamily members are of three major types, including the type 1 cystatins (stef... | |||
TMPY-01303 | Serpin A3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has be... | |||
TMPY-02717 | GPR37 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
GPR37 (cathepsin Z) is an orphan receptor that belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors are a large protein family comprised of transmembrane receptors that sense molecules outside ... | |||
TMPY-02242 | Serpin B6 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB6 / PI-... | |||
TMPY-01027 | Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. I... | |||
TMPK-01422 | Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Peptide Ready HLA-A*02:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M,... | |||
TMPK-01415 | APC-equivalent Peptide Ready HLA-A*02:01&B2M Tetramer Protein, Human, MHC (His) | Human | HEK293 Cells |
Peptide Ready HLA-A*02:01&B2M Tetramer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M... | |||
TMPK-01421 | Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
HLA-A*02:01&B2M&Peptide ready Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M,... | |||
TMPK-01420 | Peptide Ready HLA-A*03:01&B2M Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Peptide Ready HLA-A*03:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*03:01. Peptide ready MHC molecules comprising human HLA alleles and B2M,... | |||
TMPK-01410 | Peptide Ready HLA-A*24:02&B2M Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Peptide Ready HLA-G&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-G. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can b... | |||
TMPK-01419 | Peptide Ready HLA-A*03:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
Peptide Ready HLA-A*03:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*03:01. Peptide ready MHC molecules comprising human HLA alleles and B2M,... | |||
TMPK-01425 | Peptide Ready HLA-A*11:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
Peptide Ready HLA-A*11:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*11:01. Peptide ready MHC molecules comprising human HLA alleles and B2M,... | |||
TMPK-01426 | Peptide Ready HLA-A*11:01&B2M Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Peptide Ready HLA-A*11:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A*11:01. Peptide ready MHC molecules comprising human HLA alleles and B2M,... | |||
TMPK-01409 | Peptide Ready HLA-A*24:02&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
Peptide Ready HLA-G&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-G. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can b... | |||
TMPK-01455 | HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumor... | |||
TMPK-01406 | HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled | Human | HEK293 Cells |
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumor... | |||
TMPK-01432 | HLA-A*11:01&B2M&KRAS G12A (VVVGAAGVGK) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01445 | HLA-A*02:01&B2M&MAGE-A1 (KVLEYVIKV) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
MAGE-A1 belongs to the chromosome X-clustered genes of cancer-testis antigen family and is normally expressed in the human germ line but is also overexpressed in various tumors. | |||
TMPK-01468 | HLA-A*02:01&B2M&MART-1 (ELAGIGILTV) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Melanoma antigen recognized by T cell-1 (Mart-1), one of the melanosome-specific proteins, also recognized by cytotoxicity T lymphocytes as a marker. Mart-1 is considered to play a critical role in the immunotherapy for ... | |||
TMPK-01459 | HLA-A*02:01&B2M&MAGE-A4 or MAGE-A8 (KVLEHVVRV) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
MAGE-A4 and MAGE-A8 are type I membes of the melanoma associated antigen (MAGE) family. The MAGE family is a large, highly conserved group of proteins that share a common MAGE homology domain. Both MAGE-A4 and MAGE-A8 an... | |||
TMPK-01495 | HLA-A*01:01&B2M&MAGE-A3 (EVDPIGHLY) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Melanoma antigen gene A3 (MAGE-A3) is one of the most immunogenic cancer testis antigens and is common in various types of cancers. MAGE-A3 can be considered as a predictor for poor prognosis and an option for vaccine im... | |||
TMPK-01433 | HLA-A*11:01&B2M&KRAS G12C (VVVGACGVGK) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01482 | HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple ... | |||
TMPK-01496 | HLA-A*01:01&B2M&CT83 (NTDNNLAVY) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Cancer/testis antigens 83 (CT83), also called KK-LC-1 or CXorf61, recognized by cytotoxic T lymphocytes (CTL), has become a promising target for immunotherapy. | |||
TMPK-01530 | HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that sel... | |||
TMPK-01519 | HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple ... | |||
TMPK-01532 | HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell prolifer... | |||
TMPK-01515 | HLA-A*02:01&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple ... | |||
TMPK-01498 | HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that sel... | |||
TMPK-01428 | HLA-A*11:01&B2M&KRAS G12D (VVGADGVGK) Monomer Protein, Human, MHC (His & Avi) | Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01449 | HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (E. coli, His & Avi) | Human | E. coli |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,... | |||
TMPK-01404 | HLA-A*11:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (E. coli, His & Avi), Biotinylated | Human | E. coli |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01526 | HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
TMPK-01453 | HLA-A*03:01&B2M&KRAS G12V (VVVGAVGVGK) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-pr... | |||
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